The first commercial flight in nearly six years took off on Wednesday from Sana'a in war-torn Yemen to the Egyptian capital, Cairo, Anadolu News Agency report.
"A flight carrying 78 passengers left to Cairo," a source at Sana'a Airport told Anadolu Agency.
In April, Yemen's warring rivals agreed to an UN-brokered two-month truce under which all military operations were halted.
The truce agreement included the operation of commercial flights from rebel-held Sana'a Airport in the Yemeni capital.
The Airport was closed by the Saudi-led coalition since 2016, saying that its facilities were used by Houthis for military purposes, a claim denied by the rebels.
Yemen has been engulfed by violence and instability since 2014, when Iranian-aligned Houthi rebels captured much of the country, including Sana'a.
The Saudi-led coalition entered the war in early 2015 to restore the Yemeni government to power.
The eight-year conflict has created one of the worst humanitarian crises in the world, with millions suffering from hunger.